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For example, doxorubicin (DOX) has cardiac side effects that lead to irreversible dilated cardiomyopathy and congestive heart failure, and acetylcarnitine has been shown to prevent cardiac functional and structural damage caused by DOX-induced oxidative stress [289]

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Indeed, two of the genes encoding the main ATP-dependent cation pumps, ATP1A2 and ATP1A3 , are in our paroxysmal gene list and were determined to be Highly likely to be CVS related due to multiple case reports in the literature associated with intermittent vomiting

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