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Caspofungin was the 1 st FDA approved drug of the echinocandins class which came into the market during the 2000 s and was marked as a lipo- peptide antibiotic which inhibited enzyme 1,3- -D glucan synthase- the key component of the Candida cell wall [76, 77]

Robust methods are a family of methods that are robust to deviations from the distributional assumptions of parametric methods (e.g

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Each DNA template (used as the RNA template) was designed (from the 5 end) with a forward primer sequence for PCR, the target 5 UTR sequence, and a reverse primer sequence for PCR