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Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimers brain is mediated by the JNK-AP1 signaling pathway

As summarized in Table 1, current drug development efforts targeting this pathway have been predominantly focused on oncology, with comparatively limited progress in aging-related applications

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The difference is practical: a larger vial takes longer to use up, which means the last doses drawn may have experienced more cumulative degradation than the first doses