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Likewise, tumor heterogeneity means that even within the same tumor, different cell populations may respond differently to the same treatment, increasing the complexity and difficulty of therapy

Additionally, IVIVE was applied to selected mycotoxins for the derivation of the kinetics of EnB and EnB1 from cellular models by Fste et al

The present study assessed the potential hepatoprotective effects of phytic acid (PA), a natural antioxidant and iron chelator, on APAP-induced hepatotoxicity and the possible underlying mechanism through its effects on CYP2E1 gene expression, iron homeostasis, oxidative stress, and SIRT -1 expression levels

3MST localizes to mitochondria and the cytosol CBS and CSE are localized in the cytosol, while 3MST is localized in mitochondria as well as the cytosol (54, 69)