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Phytother Res 32(6):10731079

Measuring autophagosome flux

Cardiomyocytes are formidable protein synthesis factories, producing around 14,000 proteins, rendering them particularly vulnerable to accumulating toxic levels of misfolded proteins in times of stress, such as in AF due to the rapid activation rates and enhanced mechanical and metabolic stress [8]

Indeed, proteasome-dependent proteolysis of carbonylated proteins that were extensively present in late log phase epimastigote cultures was suggested to signal metacyclogenesis (Cardoso et al., Nucleotides Synthesis and DNA Replication Cellular DNA synthesis and proliferation, as well as DNA repair mechanisms depend on the production of a balanced supply of deoxyribonucleotides (dNTPs)