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Discussion High Pyroglutamic acid indicates a disturbed GSH homeostasis in symptomatic TTR-V30M gene carriers In a recent study, we demonstrated that the formation of the aggregation-prone NNTTR species, initially discovered in plasma from TTR-V30M gene carriers [21], is promoted by the formation of a disulfide bridge [22]

Sequences of real-time reverse transcription-polymerase chain reaction (RT-PCR) primers used in this study are listed in Supplementary Table 1

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Glutathione, when taken in oral or topical form, can repair the cellular structure of skin