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Cochlear explants were pretreated with 2 mM bucillamine for 1 h before the addition of 30 M cisplatin

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Clinical specimens exhibit marked metabolic protein dysregulation - PGC-1 expression decreases 65% compared to controls, concurrent with diminished UCP1 and Carnitine palmitoyltransferase 1 (CPT1) protein levels as determined by immunoblot analysis (88)