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This is why the treatment approach I'll share addresses the entire chainnot just your heel

Drager J, Harvey EJ, Barralet J (2015) Hypoxia signalling manipulation for bone regeneration

In our own study we were able to show that LIF mRNA expression was up-regulated very early mainly during the first 3 weeks of cuprizone administration in both CC and cortex thereafter decreasing to normal levels in the recovery phase after toxin withdrawal (Gudi et al., 2011)