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However, when comparing the mRNA expression of both targets between the two groups, we found the following differences: Mast cells from AD patients showed a significantly higher 5-LO mRNA expression in non-stimulated cells (24,9-fold) and in cells stimulated with IL-4 (1,70-fold) or IL-13 (85,1-fold) than in cells from HVs

Copper in the form of a labile copper ion pool as a result of metal dyshomeostasis has the capacity to oxidize dopamine, resulting in the formation of various potentially harmful species, including dopamine-quinones, superoxide radical anions (O 2 - ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals ( OH) (Monzani et al., 2019[314])

Eur J Pain 2006 May

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