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Exposure to ROS (involving H 2 O 2 )/RNS, or to compounds which can generate ROS, can increase the content of GSH by increasing the rate of GSH synthesis (2)

2 SAN Scientifically Advanced Nutrition -L- 87,5

This effect is mediated by GSH-dependent conjugation and export of anticancer drugs, diminishing their intracellular concentrations and therapeutic efficacy (5053)

(2015), this paper shows that systemic treatment with antioxidants increases survival of CTCs in the blood and promotes distant metastasis in melanoma and lung cancer mouse models