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Abstract Lewy bodies (LBs), a pathological hallmark of synucleinopathies, are heterogeneous inclusions that contain -Synuclein (Syn) alongside numerous proteins, lipids, and damaged organelles

Within the PDAC microenvironment interleukin-1 beta (IL-1) positive macrophages, prostaglandin E2, tumor necrosis factor, and lipocalin-2 can induce pro-inflammatory conditions ( Figure 3 ) (68, 88)