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Next, we applied the "DDRTree" method of the "reduceDimension" function for dimensionality reduction and used the "orderCells" function to sort cells and construct trajectories

doi: 10.1016/j.jaci.2016.01.024 47 RivireEPascaudJVironeADuprALyBPaolettiAet al

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Mechanistically, the antibodies simultaneously engage EGFR/ERBB2 on tumor cells and the NKG2D-CAR on NK cells, establishing close-range immune synapses that directly activate CAR-NK cells irrespective of endogenous NKG2D-ligand expression, thereby overcoming target-recognition loss [81]