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They note that their study has several limitations, including its reliance on self-reported acetaminophen use, which may be subject to recall bias

This underscores a potential weakness of KOG classes and KOG enrichment analysis: genes are only assigned one KOG class and due to the inherent broadness of the classes, a given designation may not be the most representative of gene function in the organism of interest

The glutathione status in humans usually begins to deteriorate around the age of around 45 and drops very quickly after the age of 60, since the Self-synthesis decreases due to age

Glutathione protects the skin cells and may even help inhibit the enzyme tyrosinase , which is responsible for melanin production