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Blocking interleukin-6 (IL-6) or tumor necrosis factor-alpha (TNF-) signaling, which decreases TRPA1 protein expression, has been demonstrated to alleviate neuropathic pain in rats with BIPN (Li et al., 2018

QA is a potent neurotoxin that promotes neuroinflammation by activating N-methyl-D-aspartate (NMDA) receptors in neurons, leading to excitotoxicity (Connell et al., 2022

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Considering the notion has been raised that sub-clinical presentation of konzo exists, these measures may allow for the identification of individuals who show similar reduced antioxidant capacity as those with konzo, but who do not show a visible physical disability, enabling the overdue refinement of the clinical features associated with this disease 3,42