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Reports that focus on reestablishing wtp53 functions have determined that PEITC (Phenethyl isothiocyanate) can favor canonical p53 activity in cell line models expressing endogenous mutp53, by promoting a wtp53-like conformational state

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Interaction with H1/3 revealed 14 docking solutions at site 5, the DNA-binding domain, where the peptide bound with a minimum energy of 56.49 kcal/mol using the sequence His-Pro-Ser-Tyr-Met-Ala-His-Pro-Ala-Arg-Lys

Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: an update