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2 a) In vivo Baseline cardiovascular parameters such as heart rate, blood pressure, electrocardiogram patterns and cardiovascular responses to several neurohumoral agonists are not altered in rats exposed to sodium arsenate (50 g As/ml) in drinking-water for 10 or 18 months (Carmignani et al., 1983, 1985)

Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP Jr (2012) Association of biochemical B12 deficiency with metformin therapy and vitamin B12 supplements: the National Health and Nutrition Examination Survey, 19992006

Cytochrome P450 oxidoreductase (POR) also promotes lipid peroxidation and induces ferroptosis with the involvement of two cofactors, Flavin mononucleotide (FMN) and Flavin adenine dinucleotide (FAD) (Koppula et al., 2021)

Protective effect of metformin against ovariectomy induced depressive-and anxiety-like behaviours in rats: role of oxidative stress