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Tieu K, Perier C, Caspersen C, Teismann P, Wu D-C, Yan S-D, et al

PL: Project administration, Writing review and editing, Supervision, Funding acquisition, Writing original draft

ASK1 goes on to bind to TRAF2, which in turn activates downstream-signaling cascades, including the MKK3/4/6p38 and MKK4/7JNK signaling pathways 36,37 (Figure 4)