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Il rame stesso un cofattore essenziale per numerosi enzimi coinvolti nella sintesi del collagene (lisil ossidasi), nella difesa antiossidante (superossido dismutasi) e nella produzione di melanina (tirosinasi)

Although mTORC1 is the primary complex that responds to amino acid availability, reintroducing amino acids to cells deprived of both serum and amino acids increases the phosphorylation of AKT by mTORC2 146 (Fig