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Description

Sp treated wild-type flies though presented a better life span than untreated controls, did not show any significant difference in their oxidative profile and neural organization

Nature 432, 353360

doi: 10.1016/j.jinorgbio.2004.07.009 156 Russell-JonesGMcEwanJ

However, when the drug is taken in an overdose, the Uridine diphosphate-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) in the human liver that participate in APAP detoxification become saturated, and a considerable proportion of this drug is activated by human CYPs (primarily CYP2E1)