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500mg daily represents the clinically studied dose for skin brightening benefits

Discussion Diabetes, Neuropathy and Vitamin B 12 Vitamin B 12 is key in nucleic acid methylation, S-adenosylmethionine and haemoglobin synthesis, and fat and protein metabolism

The gastrointestinal environment plays a crucial role in the bioavailability of HT

Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide