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Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity

Another commenter opposed any limitation on the physician's ability to modify the plan of care stating that his/her order/referral in these cases means that they are relinquishing their ability to direct the patient's care, including those occasions when during the episode of care a patient sees the physician with a change in their condition that necessitates a modification

This is because autoimmune chronic atrophic gastritis, which is associated with PA, typically results in higher-than-normal gastrin levels in the blood when fasting [7]