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As a close structural relative of GHK-Cu (Gly-His-Lys), AHK-Cu shares the copper-chelating tripeptide architecture but exhibits a distinct biological activity profile studied particularly in the contexts of hair follicle biology, angiogenesis, and skin extracellular matrix research

This issue, however, was rekindled and became a subject of debate with the 1996 approval by the US FDA of mandatory folic acid fortification of staple food products for the prevention of neural tube defectaffected pregnancies (13)

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Its value in a clinical setting comes from what it is not: it does not disrupt appetite, hormones, insulin, or IGF-1