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10.1016/j.mri.2015.12.005 226 RajP

A sensible experiment spreads doses across at least three orders of magnitude, something like 1, 10, and 100 nanomolar on up to 1 and 10 micromolar, precisely because the sweet spot moves with the copper-to-peptide ratio, the buffer, and how much serum sits in the media

Response: We appreciate the alternative methods suggested by the commenter to help mitigate the effect on hospitals of eliminating the low wage index hospitals policy

Future randomised controlled trials should specifically address this clinical question in older adults with obesity with an emphasis on efficacy, body composition and health economic modelling