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Integrated analysis of TCGA and GTEx datasets revealed significant downregulation of GABBR1 in NSCLC tumor tissues relative to adjacent normal tissues (Figure 8C) , corroborating its putative tumor-suppressive role as suggested by our earlier mechanistic studies

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In our quest for enzymes that were free from feedback inhibition and that would enable even further accumulation of glutathione, we identified two bacterial single step multicatalytic enzymes from Streptococcus thermophilus (Li et al

In addition, we reported that the plasma glutathione concentration is transiently elevated after oral glutathione supplementation [13], which suggests that exogenous glutathione can be absorbed into the body and act as an important glutathione supply