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3.6.2 Spatiotemporally controlled sustained-release platforms Microsphere/liposome systems: PLGA- or lipid-encapsulated uricase formulations achieve weeks-to-months sustained release, reducing injection frequency and improving adherence in chronic regimens (Ezike et al., 2023)

According to studies in animal models of glaucoma, the progressive RGCs death occurs mainly via apoptosis triggered by several interrelated mechanisms, including mechanical stress and impaired axonal transport of neurotrophic factors, glutamate excitotoxicity, as well as retinal ischemia and oxidative stress 8

12 In contrast, cell senescence can occur whenever under a specific stress condition, and it may also play a positive role in wound healing and tumor inhibition

An additional limitation of the study includes lack of detailed neuropsychological assessment prior and post combination treatment therapy