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Cagrilintide, a long-acting human amylin analogue, exerts both central and peripheral effects by enhancing satiety, delaying gastric emptying, and modulating postprandial glucagon secretion, whereas semaglutide acts on GLP-1 receptors in the central nervous system and peripheral tissues to regulate appetite, glycemic control, and energy balance

CLM and TMA edited the manuscript, and read and approved the final version of the manuscript and agree with the order of presentation of the authors

the 2.88 mg/kg amount produced the larger effect on neuroinflammatory cytokine markers and PI3K/AKT pathway activation [5]