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105 Although mAb against IGF-1R have shown single-agent activity, their combination with other therapies has not been promising (Table 1)

The objectives were to assess: frequency of fractures before and after stroke/TIA, predictors for fractures, and consequences on mortality, functional outcome, and quality-of-life

In some experiments, mice were intraperitoneally administrated with rIL-1 (1 g/mouse), or rIL-1ra (40 g/mouse) at 12 h before APAP challenge (200 mg/kg)