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Patients with a history of cobalt allergy may be at increased risk, as all cobalamins (including hydroxocobalamin and cyanocobalamin) contain a cobalt atom in their molecular structure

In families of patients with PA (pernicious anaemia), ulcerative colitis, rheumatoid arthritis, polymyalgia, psoriasis, sarcoidosis, lupus were in one study more common than in those of people without PA

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Structural differences: In AHK-Cu (Ala-His-Lys:Cu(II)), the alanine methyl group introduces greater lipophilicity and steric bulk near the N-terminal copper coordination site