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& El Gazzar, M

J Allergy Clin Immunol (2022) S0091-6749(22):011824

Research (PMID: 11472075) shows this modification substantially reduces binding affinity to IGF-binding proteins (IGFBPs) compared to native IGF-1, resulting in a longer circulating half-life and sustained bioavailability in research models a key reason LR3 variants are used in preference to native IGF-1 in extended-duration studies