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Results: The obtained data revealed that PPA treatment caused significant oxidative stress and neurotransmitter imbalances, characterized by reduced GABA and elevated glutamate levels

The fALS SOD1 mutants are categorized into wild-type-like (WTL), such as A4V, L38V, G37R, G41S, G72S, D76Y, D90A and G93A, that bind metals tightly and retain catalytic activity 31 , and those with impaired metal binding and reduced catalytic activity, such as H46R, H48Q, G85R, D124V, D125H, G127X and S134N 32

Third, the cross-compartmental crosstalk between mitochondria and the cytoplasm/nucleus in ferroptosis signaling is poorly characterized

Figures Abstract Background Glutathione is considered essential for survival in mammalian cells and yeast but not in prokaryotic cells