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Sharma LK, Lu J, Bai Y

A human correlate to the IL-5 transgenic mouse is the recently recognized lymphocytic variant of hypereosinophilic syndromes (see Chapter 36), in which a clonal population of T cells producing IL-5 causes persistent and profound eosinophilia and which often is responsive to anti-IL-5 (mepolizumab) therapy.1517 The ability to propagate eosinophils from bone marrow and umbilical cord stem cells is dependent on IL-5 and further substantiates its role as the most critical cytokine for eosinophil proliferation, maturation, terminal differentiation, and survival.18,19 In summary, allergen challenge, inflammatory eosinophilic disorders, and parasitic infections induce the production and release of eosinophil precursors from the bone marrow in response to endocrinological actions of cell-derived IL-5, with a contribution by CCL11

During the test session, the swimming patterns (path length) to the target area, as well as the time taken to reach the platform, were assessed and documented

Test, rinse, repeat: a review of carryover effects in rodent behavioral assays