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Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded

Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (air-bx1 and air-bx2): Two randomised double-blind, placebo-controlled phase 3 trials

The resulting RNA-VQ-TGIRT complex was parameterized and output as Amber prmtop and inpcrd files, as well as a PDB reference file, for downstream MD simulations