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When activated within the skin, the patient can experience irritation, swelling, hives, and dermatitis

Increase in homocysteine as vitamin B12 levels decrease below 250 pmol/L from Elmadfa and Singer 2009 Increase in MMA as serum vitamin B12 decreases below 250 pmol/L - from Shobha etal, 2011 Many people, however, experience symptoms of vitamin B12 deficiency yet their serum levels of vitamin B12 may be normal or much higher than normal

Yes, but oral use is typically better suited as a complement, not a substitute, for direct administration methods like injections or IV

The transfusion is performed in a hospital or medical center