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Its mechanism of action involves activating the PI3K-AKT signaling pathway, promoting the migration of human umbilical vein endothelial cells and the expression of CD31 and vascular endothelial growth factor to enhance angiogenesis, while inhibiting the release of inflammatory factors such as IL-1 and IL-6 in THP-1 cells and inducing M2 macrophage polarization (49)

CVD risk assessment should complement other dementia biomarker assessments

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More clinical trial information on the application of CDK4/6 inhibitors in various breast cancers [36,37,38,39,40] is demonstrated in Table 1