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In CRC, SHMT2 has been shown to bind competitively to the cytosolic p53 protein, thereby sequestering the E3 ubiquitin ligase HDM2(Human double minute 2), thereby inhibiting autophagy and conferring resistance to 5-fluorouracil (5-FU) chemotherapy [104]

A (retinol) (IVW OR: 1.32

These systems are unique in that they have a hydrophobic core that functions as an efficient carrier for the delivery of hydrophobic drugs, Paclitaxel [53], Budesonide [95], and Celecoxib [96], and a very hydrophilic polysaccharide backbone that serves as a shell for such poorly water-soluble pharmaceuticals

Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet