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Kyn, 3OHK and 3OHKG are found prominently in young lenses (102), but decline at a rate of ~12% per decade, with kyn and 3OHK being nearly undetectable in 80 year old lenses (110)

Conversely, the inhalation trials exposure of only 20 min per day may not be sufficient to achieve an effective central concentration (Yoritaka et al., 2016

Collectively, these novel antioxidants may be a feasible method to alleviate and prevent ROS-related hearing loss

To test the function of the cyclin D-Rb interaction, we examined immortalized human mammary epithelial cells (HMECs) expressing doxycycline-inducible Rb variant proteins fused to Clover fluorescent protein and 3FLAG affinity tags (Figure 5A-B and S6A-B)