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Previous work from our and other labs has demonstrated that mitochondrial GSH is critical for cell viability, and indeed we find that cells with uncoupled mitochondrial and cytosolic GSH remain sensitive to inhibition of mitochondrial GSH transport or disruption of mitochondrial functionality

To establish a direct association between HMGA1 and HK2 transcription, we introduced mutations into the HMGA1 binding sites within the HK2 promoter and subsequently conducted a luciferase reporter assay to evaluate HMGA1s specific binding capability to the HK2 promoter

doi:10.22271/tpi.2022.v11.i10b.16893 6

[Google Scholar] Devi, K