glutathione peroxidase 1 brain GPX1 and Its Dichotomous Roles in Cancer Superoxide dismutase (SOD) and Glutathione

Annu Rev Pharmacol Toxicol 44:32547, PMID: 14744249 Holmgren A, Lu J (2010) Thioredoxin and thioredoxin reductase: current research with special reference to human disease

Older patients with depressive and anxiety disorders are susceptible to the age-related acute and chronic brain and physical illnesses, including metabolic, endocrine and neurobiological disorders,1 and are at high risk for cardiovascular, and cerebrovascular comorbidities.2 The significant heterogeneity in geriatric depression results in difficulties in both comparing research findings and identifying biomarkers to establish homogeneous subgroups for depression personalized therapy.3 Since oxidative stress is associated with depression,4 it is reasonable to search for such biomarkers among antioxidant systems, i.e

10.1016/j.sajb.2021.06.025 [Google Scholar] Richard SA, Manaphraim NYB, Kortei NK (2020) The Novel Neurotoxic and Neuroimmunotoxic Capabilities of Aflatoxin B1 on the Nervous System: A Review

Another advantage is that the present invention enables administration of a larger quantity of either GSH of methylcobalamin in a single dose than other forms of non-parenteral administration as well as enabling incremental adjustment of doses for children and adults