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PMID: 80 CarmonaACarboniEGomesLCRoudeauSMaassFLenzCet al

Beyond their role in ATP production, mitochondria function as stress sensors that transmit retrograde signals to the nucleus, thereby reshaping gene-expression programs and determining whether a cell adapts or undergoes death

Since then, more than 60 peptide-based drugs have been greenlit not because they're experimental, but because they work with your biology, not against it