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Deficiency can be due to inadequate dietary intake, especially in vegans, but is otherwise more likely due to problems with absorption, which is more complex than that of other vitamins

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Notably, the FM IgG was found to bind to both human and murine satellite glial cells (SGCs) in the dorsal root ganglia (DRGs) (anti-SGC IgG)

Chronic depression alters phospholipid metabolism, reduces serum polyunsaturated fatty acids (PUFAs), and disrupts thyroid hormone-regulated lipid profiles (200202), creating a lipid milieu favorable for Mtb persistence