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Discussion BPC 157 has been shown to exert beneficial effects against different pathological conditions [1,2,1026], it induced gastroprotective, analgesic and anti-inflammatory wound healing effects [1,2,1017], also effective against experimental colitis [1016] and showing a particular interaction with the NO-system [14,15,1826]

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High-dose supplementationparticularly intramuscular injections that can deliver 1,000 micrograms or morecreates substantially elevated serum B12 levels compared to dietary intake, which may more readily trigger these bacterial changes, though comparative studies between different forms are limited