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References NIH Office of Dietary Supplements: Vitamin B12 Fact Sheet for Health Professionals National Heart, Lung, and Blood Institute: Vitamin B12-Deficiency Anemia FDA: Advises Consumers Not to Inhale Nitrous Oxide Products, March 2025 Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study, Journal of Clinical Endocrinology and Metabolism UCSF: B12 Levels Within the Normal Range Linked to Cognitive Decline, Annals of Neurology Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications

Physiologically-based TK and population-based TK models account for these factors allowing for the estimation of a range of internal doses that more accurately reflect the diversity of population responses

O., Yoon, S

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