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Usually, polyphenols in foods - except for the flavanols members - are in conjugated form (with carbohydrates), altering their solubility, digestion, and absorption properties, favoring their degradation and greatly limiting their absorption [52]

The cumulative effect of these factors - protection from digestive degradation, improved cellular uptake, sustained release, and reduced first-pass metabolism - is significantly enhanced bioavailability

39 Micro-computed tomography analysis At 1, 2, and 3 months postoperatively, SD rats were sacrificed, and spines were excised and fixed in a 1.5% phosphate-buffered glutaraldehyde solution