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Kava lactones and the kava-kava controversy

Andean populations demonstrate a typical polycythemic response marked by heightened hemoglobin levels and increased erythrocyte mass, a mechanism that enhances arterial oxygen content but imposes the pathophysiological burden of elevated blood viscosity and susceptibility to chronic mountain sickness (CMS) (65)

Schedule Appropriate Follow-Up: INR 4.0: Contact doctor today INR 1.8-2.0 or 3.5-4.0: Call within 24 hours INR 2.0-3.5: Continue current schedule Helpful Resources: Track patterns across multiple health metrics using our Health Tips section Understand related test results with our CBC test guide Learn about clot symptoms at our blood clots resource Medical Disclaimer: This article provides educational information about PT/INR test interpretation and is not medical advice

Only about 17% of patients under 10 years of age are found to have neuropsychiatric symptoms at presentation, whereas in patients presenting after 18 years of age, 74% experience neurologic manifestations.2,20 It is usually after 10 years of age that patients may manifest evidence of involvement of the other organ systems such as renal, hematologic, and endocrine (Figure 252)