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Moreover, HGF also inhibited phosphorylation of PKR [T451], which is known to have antiproliferative and pro-apoptotic functions

Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats

Therefore, an amplification loop sustaining mitochondrial dysfunction in APAP-mediated hepatotoxicity has been suggested, involving two hits

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Lpez-Samanes ., Prez-Lopez A., Morencos E., Muoz A., Khn A., Snchez-Migalln V., Moreno-Prez V., Gonzlez-Frutos P., Bach-Faig A., Roberts J., et al