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In addition, animals in different groups showed a similar weight gain during the course of the experiment (Table S2)

Intestinal barrier dysfunction and dysbiosis can lead to translocation of bacterial lipopolysaccharide (LPS) and gut-derived toxins into the systemic circulation, triggering systemic low-grade inflammation ( Traditional nutritional management of DKD has primarily focused on single-nutrient interventions such as protein restriction, glycemic control, and blood pressure management

For example, using the KAT2A-targeting inhibitor MB-3 (57) and the CBP-targeting inhibitor SGC-CBP30 (126) restores sensitivity to cisplatin