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Unlike nuclear DNA, circular mtDNA lacks protective histones, making it more susceptible to oxidative stress-induced damage (69)

Hippocampal neurometabolite changes in hypothyroidism: an in vivo 1H magnetic resonance spectroscopy study before and after thyroxine treatment

Interstitial lung disease may precede the myopathy or occur early in the course of the disease, especially in patients who have anti-Jo-1 antibodies or antibodies to other synthetases, as discussed later