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doi:10.1016/j.autrev.2009.02.020

Collectively, these data from yeast show that methionine while strongly drive anabolic processes, all these are closely tied to NADPH synthesis and utilization

Savage, J., Sicherer, S

In general, gene mutations with large biological effects (i.e., optic neuropathy) are rare whereas gene variants associated with smaller effects are common (12) (see below)