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The cholesterol synthesis pathway is also significantly altered in astrocytes from aged mice (24-months-old), likely contributing to the observed decline of cholesterol in the aged brain and potentially hindering production of myelin (Boisvert et al., 2018

In other words, the conserved serine in the active site of Ser-GSTs does not play the role of the catalytic residue

And because it actually works repairing the skin barrier rather than just coating the surface, the results carry through the day

However, the long-term use of ketoconazole may lead to liver toxicity and hypogonadism [165], presenting challenges for clinical application in SS treatment