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Their seeds are some of the best flyers in nature, catching the wind and spreading as far as 100 kilometres

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6.4 Immunomodulatory therapies Immunomodulation has emerged as a promising investigational approach in PD, supported by evidence that microglial activation, inflammasome signaling, and peripheral immune dysregulation may contribute to neurodegenerative processes

Thus, SUMOylation may be an early line of defense to regulate TDP-43 in response to stress and blocking TDP-43 SUMOylation shifts proteostasis leading to delayed recovery